Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease
Globoid cell leukodystrophy (Krabbe disease) is a fatal neurodegenerative, demyelinating disease Horse Reins caused by dysfunctional activity of galactosylceramidase (GALC), leading to the accumulation of glycosphingolipids including psychosine.While oligodendrocytes have been extensively studied due to their high levels of GALC, the contribution o